Abstract: Introduction: Mucous membrane manifestations of Behcet's Disease (BD) are the most important and frequent lesions of the disease. The classic lesions are well known. Other forms exist that are not given usually enough attention. Mucous Membrane Manifestations: The classical lesions are the oral and the genital aphthosis. 0ther forms are: 1- Rare forms of oral aphthosis: a/- Punctiform aphthous lesions: They are small and difficult to see. b/- The miliaria aphthosis: It ...
Abstract: Introduction: Different methods of treatment were employed in ocular lesions of Behcet’s disease (BD) in adults. Most of them are not permitted in children due to their potential toxicity. Methotrexate (MTX) has gained wide acceptance for the treatment of childhood rheumatic diseases. On the other hand, we showed in several reports the efficacy of MTX in the treatment of ocular lesions of BD. This study was designed to show the ...
Abstract: INTRODUCTION: Ocular lesions of Behcet's Disease (BD) progress usually toward severe loss of vision or blindness, if not aggressively treated. Cytotoxic drugs are the main therapeutic arsenals used for it: Low dose methotrexate (MTX) by its safety and its efficacy is one of the best therapeutic choices. MATERIALS &METHODS: MTX was used as 7.5 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. Upon the suppression of the inflammatory reaction, prednisolone ...
Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) usually progress toward severe loss of vision or blindness, if not aggressively treated. The aim of this study is to evaluate the efficacy of Pulse Cyclophosphamide (PCP) in a cohort study. Methods: This study includes all patients treated with PCP from 1986 to 1998, for active PU and or RV. PCP was administered as Ig cvclophosphamide/m2/body surface, once per month. Prednisolone was given ...
Abstract: Introduction: Ocular lesions are the leading cause of morbidity in Behcet’s disease (BD). Many factors contribute to the loss of vision in BD, as uveitis, retinal vasculitis, and their secondary complications such as cataract, hemorrhage, vessel necrosis, neovascularization, optic atrophy, etc. The purpose of this study was to determine the impact of retinal vasculitis on the evaluation of ocular Behcet’s (OB) and its outcome after an early or late treatment. Materials & ...
Abstract: Behcet's Disease (BD) is classified among the Vasculitides. It is characterized by mucocutaneous and ophthalmologic manifestations and seen mostly in the Northern Hemisphere and in countries along the silk road. The characteristics of BD are presented here in a nation wide analysis of 3443 patients in Iran over a 21 year period. There was a slight male preponderance M.F ratio 1.4:1 (53.3% male/46.7% female). The mean age of onset was ...
Abstract: Introduction: We reported last year, during the ACR annual meeting, the result of different treatment modalities for ocular lesions of BD in 856 patients. We showed that pulse cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), oral cyclophosphamide (OCP), weakly methotrexate (MTX), chloambucil (CHL), and cyclosparine A (CYA) had all the same efficacy. The percentage of the eyes aggravated (visual acuity) despite the treatment was: For PCP: 21%, LDP: 22%, OCP: ...
Abstract: Behcet's disease (BD) is not ran in Iran. The annual incidence is around 345 patients for a population of 60 millions. The male/female ratio is 1. 13. The mean age at the onset of the disease is 26.2+9.7 years (CI at 95%=0 .4). The prevalence of clinical signs were as follow: Mucous membrane lesions 96%+0.7 (oral aphthosis 95.7%, genital aphthosis 64%); skin lesions 74%±I.5 (pseudofolliculitis 66%, erythema nodosum 23%): ocular ...
Abstract: Considering that the majority of BD patients are from APLAR (Asia and Pacific League of Associations for Rheumatology) countries any diagnosis criteria for BD must have an adequate accuracy in these countries. The APLAR subcommittee for Behcet's Disease has set a prospective study to assess the accuracy of the existing diagnosis criteria. China, Iran, Japan, and Korea, the major countries with BD are participating to this study. The data from ...
Abstract: Introduction: Ocular lesions are the major cause of morbidity in Behcet's Disease. If not treated, they usually progress toward severe loss of vision or blindness. Cytotoxic drugs are the main therapeutic arsenal used for this condition. Materials & Methods: in an open, non randomized control study. Pulse Cyclophosphamida (PCP), low dose pulse cyclophosphamide (LDP), oral cyclophosphamide (OCP). weakly methotrexate (MTX), chlorambucil (CHL), and cyclosporine A (CYA) were used in a standard ...